Figure 4: Complex insertion and translocation of case MI6 detected by mate-pair genome sequencing. Bars in red, green, and orange indicate chromosomal segments in chromosomes 3, 4, and 20, respectively. Each dotted line indicates the breakpoint locus on each chromosome. Bars in white present cryptic chromosomal segment in 3q13.32q28 indicating there are 22 segments after chromosome scatting. Characters in a reverse direction indicate a reverse orientation of the chromosomal segments in derivative chromosomes. Disruption of candidate genes associated with male infertility is shown above the chromosomes. Copy number losses of four chromosome segments originating on chromosome 3 are indicated in a dotted frame. TP63: tumor protein p63; chr: chromosome; der: derivative chromosome.