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  Indian J Med Microbiol
 

Figure 5: Identification of the 15-AS-event score for predicting TGCT progression. (a) The LASSO regression model was conducted to screen the pivotal hazard AS events and we illustrated the convergence curve, in which Log(Lambda) represented the horizontal axis, and coefficients represented the vertical axis. (b) Accordingly, the LASSO method selected 15 events from 300 potentially PFS-related AS events. (c) Receiver operating characteristic curve of the ability of the ASS to predict 5-year progression. (d) Kaplan–Meier analysis of PFS-related survival of TGCT patients according to the ASS. High and low ASS scores represent more than or less than the median ASS, respectively. P = 1.462 × 10−7 by log-rank test. AS: alternative splicing; ASS: AS score; PFS: progression-free survival; TGCT: testicular germ cell tumors; ROC: receiver operating characteristic; AUC: area under the curve; LASSO: least absolute shrinkage and selection operator.

Figure 5: Identification of the 15-AS-event score for predicting TGCT progression. (<b>a</b>) The LASSO regression model was conducted to screen the pivotal hazard AS events and we illustrated the convergence curve, in which Log(Lambda) represented the horizontal axis, and coefficients represented the vertical axis. (<b>b</b>) Accordingly, the LASSO method selected 15 events from 300 potentially PFS-related AS events. (<b>c</b>) Receiver operating characteristic curve of the ability of the ASS to predict 5-year progression. (<b>d</b>) Kaplan–Meier analysis of PFS-related survival of TGCT patients according to the ASS. High and low ASS scores represent more than or less than the median ASS, respectively. <i>P</i> = 1.462 × 10<sup>−7</sup> by log-rank test. AS: alternative splicing; ASS: AS score; PFS: progression-free survival; TGCT: testicular germ cell tumors; ROC: receiver operating characteristic; AUC: area under the curve; LASSO: least absolute shrinkage and selection operator.