Close
  Indian J Med Microbiol
 

Figure 2: MAGI-2 expression profiles in our 65 pairs of tumor–normal tissue sequencing data, TCGA database, GEO database, and tissue microarray. (a) Comparison of MAGI-2 mRNA relative expression between tumor and benign tissue in our 65 pairs of tumor–normal tissue sequencing data (P = 0.0003). MAGI-2 mRNA relative expression pattern among (b) tumor stages (P = 0.8599) and (c) pathological lymph node status in our 65 pairs of tumor–normal tissue sequencing data (P = 0.489). (d) Comparison MAGI-2 mRNA relative expression between tumor and benign tissue in the TCGA database (P < 0.0001). MAGI-2 mRNA relative expression pattern among (e) tumor stages (P = 0.0096) and (f) lymph node categories (P = 0.0022) in the TCGA database. Comparison of MAGI-2 mRNA relative expression (g) between Gleason score ≤6 and Gleason score ≥7 (P < 0.0001) and (h) among T2 and T3 or T4 (P = 0.0061) in GSE21034. MAGI-2 mRNA relative expression in metastatic tumor is statistically significantly elevated than primary tumor in (i) GES21034 (P < 0.0001) and (j) GSE6752 (P < 0.0001). Comparison of MAGI-2 protein expression (k) between tumor tissue and benign tissue (P = 0.7076), among different (l) pathological tumor stages (P = 0.0206) and (m) preoperation PSA levels (P = 0.044). (n) Comparison of preoperation PSA levels between patients with high or low MAGI-2 protein expression (P = 0.0329). A positive correlation was identified between MAGI-2 and PTEN expressions through (o) TCGA database (r = 0.4376, P < 0.0001) and (p) tissue microarray data (r = 0.4292, P < 0.0001). MAGI-2: membrane-associated guanylate kinase (MAGUK) family protein MAGUK invert 2; T2: tumor stage 2; T3: tumor stage 3; T4: tumor stage 4; pN0: pathology lymph node 0; pN1: pathology lymph node 1; PSA: prostate-specific antigen; TCGA: The Cancer Genome Atlas; GEO: Gene Expression Omnibus; PTEN: phosphatase and tensin homolog deleted on chromosome 10.

Figure 2: MAGI-2 expression profiles in our 65 pairs of tumor–normal tissue sequencing data, TCGA database, GEO database, and tissue microarray. (<b>a</b>) Comparison of <i>MAGI-2</i> mRNA relative expression between tumor and benign tissue in our 65 pairs of tumor–normal tissue sequencing data (<i>P</i> = 0.0003). <i>MAGI-2</i> mRNA relative expression pattern among (<b>b</b>) tumor stages (<i>P</i> = 0.8599) and (<b>c</b>) pathological lymph node status in our 65 pairs of tumor–normal tissue sequencing data (<i>P</i> = 0.489). (<b>d</b>) Comparison <i>MAGI-2</i> mRNA relative expression between tumor and benign tissue in the TCGA database (<i>P</i> < 0.0001). <i>MAGI-2</i> mRNA relative expression pattern among (<b>e</b>) tumor stages (<i>P</i> = 0.0096) and (<b>f</b>) lymph node categories (P = 0.0022) in the TCGA database. Comparison of <i>MAGI-2</i> mRNA relative expression (<b>g</b>) between Gleason score ≤6 and Gleason score ≥7 (<i>P</i> < 0.0001) and (<b>h</b>) among T2 and T3 or T4 (<i>P</i> = 0.0061) in GSE21034. <i>MAGI-2</i> mRNA relative expression in metastatic tumor is statistically significantly elevated than primary tumor in (<b>i</b>) GES21034 (<i>P</i> < 0.0001) and (<b>j</b>) GSE6752 (<i>P</i> < 0.0001). Comparison of MAGI-2 protein expression (<b>k</b>) between tumor tissue and benign tissue (<i>P</i> = 0.7076), among different (<b>l</b>) pathological tumor stages (<i>P</i> = 0.0206) and (<b>m</b>) preoperation PSA levels (<i>P</i> = 0.044). (<b>n</b>) Comparison of preoperation PSA levels between patients with high or low MAGI-2 protein expression (<i>P</i> = 0.0329). A positive correlation was identified between MAGI-2 and PTEN expressions through (<b>o</b>) TCGA database (<i>r</i> = 0.4376, <i>P</i> < 0.0001) and (<b>p</b>) tissue microarray data (<i>r</i> = 0.4292, <i>P</i> < 0.0001). MAGI-2: membrane-associated guanylate kinase (MAGUK) family protein MAGUK invert 2; T2: tumor stage 2; T3: tumor stage 3; T4: tumor stage 4; pN0: pathology lymph node 0; pN1: pathology lymph node 1; PSA: prostate-specific antigen; TCGA: The Cancer Genome Atlas; GEO: Gene Expression Omnibus; PTEN: phosphatase and tensin homolog deleted on chromosome 10.