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  Indian J Med Microbiol
 

Figure 1: Combination therapy with SVF and Ad-COMP-Ang1 gene restores erectile function. (a) Representative ICP responses for age-matched control mice (C) group and STZ-induced diabetic mice stimulated at 2 weeks after intracavernous injection of PBS (P, 20 μl), ad-LacZ (L, 2 × 108 particles per 20 μl), SVF (S, 1 × 105 cells per 20 μl), Ad-COMP-Ang1 (CA, 2 × 108 particles per 20 μl), or combination (S + CA). The stimulus interval is indicated by a solid bar (1 min). (b) Representative ICP responses at 4 weeks. Ratios of (c) mean maximal ICP and (d) total ICP (area under the curve) to MSBP for each group in two weeks. Ratios of (e) mean maximal ICP and (f) total ICP (area under the curve) to MSBP for each group in four weeks. Each bar depicts the mean value ± standard deviation from n = 5 animals per group. *P < 0.001, P or L versus C group. #P < 0.05, S or CA or S + CA versus P or L groups. Each bar depicts the mean value ± standard deviation from n = 5 animals per group. The P values were determined by one-way ANOVA. Ad-COMP-Ang1: adenovirus-mediated cartilage oligomeric matrix angiopoietin-1; DM: diabetes mellitus; ICP: intracavernous pressure; MSBP: mean systolic blood pressure; PBS: phosphate-buffered saline; STZ: streptozotocin; SVF: stromal vascular fraction.

Figure 1: Combination therapy with SVF and <i>Ad-COMP-Ang1</i> gene restores erectile function. (<b>a</b>) Representative ICP responses for age-matched control mice (C) group and STZ-induced diabetic mice stimulated at 2 weeks after intracavernous injection of PBS (P, 20 μl), ad-LacZ (L, 2 × 10<sup>8</sup> particles per 20 μl), SVF (S, 1 × 10<sup>5</sup> cells per 20 μl), <i>Ad-COMP-Ang1</i> (CA, 2 × 10<sup>8</sup> particles per 20 μl), or combination (S + CA). The stimulus interval is indicated by a solid bar (1 min). (<b>b</b>) Representative ICP responses at 4 weeks. Ratios of (<b>c</b>) mean maximal ICP and (<b>d</b>) total ICP (area under the curve) to MSBP for each group in two weeks. Ratios of (<b>e</b>) mean maximal ICP and (<b>f</b>) total ICP (area under the curve) to MSBP for each group in four weeks. Each bar depicts the mean value ± standard deviation from <i>n</i> = 5 animals per group. <sup>*</sup><i>P</i> < 0.001, <i>P</i> or L versus C group. <sup>#</sup><i>P</i> < 0.05, S or CA or S + CA versus <i>P</i> or L groups. Each bar depicts the mean value ± standard deviation from <i>n</i> = 5 animals per group. The <i>P</i> values were determined by one-way ANOVA. <i>Ad-COMP-Ang1</i>: adenovirus-mediated cartilage oligomeric matrix angiopoietin-1; DM: diabetes mellitus; ICP: intracavernous pressure; MSBP: mean systolic blood pressure; PBS: phosphate-buffered saline; STZ: streptozotocin; SVF: stromal vascular fraction.