Figure 4: Multiple methylated CpG dinucleotides are negatively associated with the expression of SRD5A2. (a) Schematic diagrams of 14 methylated CpG dinucleotides in the sequence from −1009 bp to +922 bp in SRD5A2. (b) The methylation ratios of the 14 CpG dinucleotides in the weakly positive group were higher than those in the strongly positive group. (c) Spearman's rank correlation between the methylation ratios of seven methylated CpG dinucleotides and the expression of SRD5A2. TSS: transcription start site; SRD5A2: 5-α reductase type 2; CpG: cytosine-phosphate-guanine.