Asian Journal of Andrology

INVITED REVIEW
Year
: 2016  |  Volume : 18  |  Issue : 3  |  Page : 392--401

Current updates on laboratory techniques for the diagnosis of male reproductive failure


Suresh C Sikka, Wayne JG Hellstrom 
 Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana, USA

Correspondence Address:
Dr. Suresh C Sikka
Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana
USA

The incidence of male reproductive failure leading to infertility, whether due to delayed parenthood, environmental issues, genetic factors, drugs, etc., is increasing throughout the world. The diagnosis and prognosis of male subfertility have become a challenge. While the basic semen assessment has been performed for many years, a number of studies question the value of the traditional semen characteristics. This is partly due to inadequate methods and standardization, limited knowledge of technical requirements for quality assurance, and an incomplete understanding of what clinical information a semen assessment can provide. Laboratories currently performing semen and endocrine assessment show great variability. The World Health Organization (WHO) manual for the evaluation of semen has been the core of andrology and fertility evaluation that has helped in further development of this field over many years. These include the physical appearance of the ejaculate, assessments of sperm count, motility, vitality, morphology, and functional aspects of the sperm and semen sample. These tests also include male endocrine profile, biochemical evaluation of the semen, detection of antisperm antibodies in serum, the use of computer-aided sperm analysis (CASA), sperm DNA integrity, and its damage due to oxidative stress. Assisted reproductive techniques (e.g., IVF, ICSI) have shown great success but are too expensive. Further development in this field with newer techniques and extensive training/instructions can improve accuracy and reduce variability, thus maintaining the quality and standards of such an evaluation. There is an urgent need to have standardized training centers and increased awareness in this area of men«SQ»s health for reproductive success.


How to cite this article:
Sikka SC, Hellstrom WJ. Current updates on laboratory techniques for the diagnosis of male reproductive failure.Asian J Androl 2016;18:392-401


How to cite this URL:
Sikka SC, Hellstrom WJ. Current updates on laboratory techniques for the diagnosis of male reproductive failure. Asian J Androl [serial online] 2016 [cited 2021 Jan 18 ];18:392-401
Available from: https://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=3;spage=392;epage=401;aulast=Sikka;type=0