Asian Journal of Andrology

REVIEW
Year
: 2015  |  Volume : 17  |  Issue : 3  |  Page : 471--474

Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network


George Kulik 
 Life Sciences Program, College of Science, Alfaisal University, Riyadh 11533, Saudi Arabia; Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA

Correspondence Address:
George Kulik
Life Sciences Program, College of Science, Alfaisal University, Riyadh 11533, Saudi Arabia; Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA

Targeting the androgen receptor axis provides only temporary relief for advanced prostate cancer, which often evolves into androgen-independent disease. The wide variety of signaling mechanisms connected with the pathophysiology of androgen-independent prostate cancer poses both conceptual and practical challenges for the design of efficient therapies. Analysis of apoptosis regulation in prostate cancer suggests the potential value of a systems approach that integrates information on the topology of the antiapoptotic signaling network, the signal transduction pathways that inhibit apoptosis, and the expression of proteins of the Bcl2 family. This approach could be used to identify patients most likely to respond to treatments with drugs that inhibit the signaling pathways controlling apoptosis.


How to cite this article:
Kulik G. Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network.Asian J Androl 2015;17:471-474


How to cite this URL:
Kulik G. Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network. Asian J Androl [serial online] 2015 [cited 2021 Sep 18 ];17:471-474
Available from: https://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=3;spage=471;epage=474;aulast=Kulik;type=0