Asian Journal of Andrology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 16  |  Issue : 5  |  Page : 774--777

Redundant prepuce increases the odds of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)


Yu-Yang Zhao, Dong-Liang Xu, Fu-Jun Zhao, Bang-Min Han, Yi Shao, Wei Zhao, Shu-Jie Xia 
 Department of Urology, Shanghai First People's Hospital, Institute of Urology, Shanghai Jiao Tong University, Shanghai, China

Correspondence Address:
Shu-Jie Xia
Department of Urology, Shanghai First People«SQ»s Hospital, Institute of Urology, Shanghai Jiao Tong University, Shanghai
China
Wei Zhao
Department of Urology, Shanghai First People«SQ»s Hospital, Institute of Urology, Shanghai Jiao Tong University, Shanghai
China

Some published evidence has revealed that the dendritic cells can interact with pathogens that exist in the inner foreskin. This information provides a new vision that pathogens could play a role through the redundant prepuce; numerous studies have failed to find pathogens in prostates of patients who had chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). However, no studies have reported an association between foreskin length and CP/CPPS. Hence, we conducted a retrospective case-control study of clinical data from 322 CP/CPPS patients (case group) and 341 nonCP/CPPS patients (control group). Demographic characteristics, lifestyle factors, and foreskin lengths were collected and analyzed. Multivariate logistic regression was adopted to calculate the odds of foreskin length for CP/CPPS. According to the multivariate logistic regression results, when the foreskin length covered up more than half of the glans penis, the odds for CP/CPPS were higher with an increased foreskin (odds ratio (OR): 1.66, 95% confidence interval (CI): 1.04-2.66). In comparison, when the glans penis was completely covered by the foreskin, the OR value increased to 1.86 (95% CI, 1.2-2.88). The study results showed an association between foreskin length and the odds of CP/CPPS. When the foreskin length covered up more than half of the glans penis, there were greater odds for CP/CPPS. This possible mechanism might result from interaction between pathogens and DCs in the inner foreskin, consequently activating T-cells to mediate allergic inflammation in the prostate and producing the autoimmunizations causing CP/CPPS.


How to cite this article:
Zhao YY, Xu DL, Zhao FJ, Han BM, Shao Y, Zhao W, Xia SJ. Redundant prepuce increases the odds of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).Asian J Androl 2014;16:774-777


How to cite this URL:
Zhao YY, Xu DL, Zhao FJ, Han BM, Shao Y, Zhao W, Xia SJ. Redundant prepuce increases the odds of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Asian J Androl [serial online] 2014 [cited 2021 Jul 27 ];16:774-777
Available from: https://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=5;spage=774;epage=777;aulast=Zhao;type=0