Asian Journal of Andrology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 16  |  Issue : 4  |  Page : 602--606

Comparison of sperm retrieval and reproductive outcome in azoospermic men with testicular failure and obstructive azoospermia treated for infertility


Sandro C Esteves1, Christina Prudencio1, Bill Seol1, Sidney Verza1, Christopher Knoedler2, Ashok Agarwal2 
1 ANDROFERT, Center for Male Reproduction, Campinas, Brazil
2 Center for Reproductive Medicine, The Cleveland Clinic Foundation, Cleveland, USA

Correspondence Address:
Sandro C Esteves
ANDROFERT, Center for Male Reproduction, Campinas
Brazil

We assessed the rates of sperm retrieval and intracytoplasmic sperm injection outcomes, including the neonatal profile of infants conceived, in men with testicular failure. Three-hundred and sixty-five men with testicular failure who underwent micro-dissection testicular sperm extraction were included in this study. We compared their outcomes with 40 men with testicular failure who used donor sperm for injections due to failed retrieval, and 146 men with obstructive azoospermia who underwent percutaneous sperm retrieval. The retrieval rate in testicular failure was 41.4%, and the results were lower than the obstructed azoospermia (100%; adjusted odds ratio: 0.033; 95% CI: 0.007-0.164; P< 0.001). Live birth rates after sperm injections were lower in men with testicular failure (19.9%) compared with donor sperm (37.5%; adjusted OR: 0.377 (95% CI: 0.233-0.609, P< 0.001)) and obstructive azoospermia (34.2%; adjusted OR: 0.403 (95% CI: 0.241-0.676, P= 0.001). Newborn parameters of infants conceived were not significantly different among the groups. We concluded that the chances of obtaining sperm on retrieval and achieving a live birth after intracytoplasmic sperm injection (ICSI) are reduced in men with testicular failure. The profile of infants conceived after sperm injection does not seem to be negatively affected by testicular failure.


How to cite this article:
Esteves SC, Prudencio C, Seol B, Verza S, Knoedler C, Agarwal A. Comparison of sperm retrieval and reproductive outcome in azoospermic men with testicular failure and obstructive azoospermia treated for infertility.Asian J Androl 2014;16:602-606


How to cite this URL:
Esteves SC, Prudencio C, Seol B, Verza S, Knoedler C, Agarwal A. Comparison of sperm retrieval and reproductive outcome in azoospermic men with testicular failure and obstructive azoospermia treated for infertility. Asian J Androl [serial online] 2014 [cited 2021 Jan 26 ];16:602-606
Available from: https://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=4;spage=602;epage=606;aulast=Esteves;type=0