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Complications and management of penile augmentation with hyaluronic acid injection

1 Department of Urology, Peking University People's Hospital, Beijing 100044, China
2 Department of Dermatology and Venereology, Peking University People's Hospital, Beijing 100044, China
3 Department of Nephrology Division, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, China
4 Department of Urology, Chengdu Kowloon Hospital, Chengdu 614000, China

Correspondence Address:
Xiao-Wei Zhang,
Department of Urology, Peking University People's Hospital, Beijing 100044
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aja.aja_78_20

PMID: 33533738

Hyaluronic acid injection is becoming a popular way for penile augmentation. However, only few studies and follow-ups have investigated the various complications of hyaluronic acid injection and their corresponding management. In this study, a total of 230 patients who had penile augmentation with hyaluronic acid injection from January 2018 to December 2019 were examined on follow-up for penile girth, complications, and their corresponding management. At 1-month, 3-month, and 6-month postoperative follow-ups, the penile circumference had increased by 2.66 ± 1.24 cm, 2.28 ± 1.02 cm, and 1.80 ± 0.83 cm, respectively. During the entire 6-month follow-up, 4.3% had complications such as subcutaneous bleeding, subcutaneous nodules, and infection. There were no systemic or local allergic reactions among all the patients. All complications were treated accordingly, and no further deterioration or severe sequelae were observed. Although complications of hyaluronic acid injections are mild and rare, these may affect the patient's satisfaction postoperatively. Preoperative redundant prepuce may increase the incidence of penile edema or postoperative gel migration. Standardization of the surgery protocol and elucidation of the effects of other injection parameters are still lacking. Nevertheless, it still highlights the importance of preoperative preparation and surgical technique.

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