Clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection with fresh or cryopreserved sperm in patients with nonobstructive azoospermia Zhang HL, Mao JM, Liu DF, Zhao LM, Tang WH, Hong K, Zhang L, Lian Y, Lin HC, Jiang H,

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Clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection with fresh or cryopreserved sperm in patients with nonobstructive azoospermia Hong-Liang Zhang^1,2,3, Jia-Ming Mao^1,2, De-Feng Liu^1,2, Lian-Ming Zhao^1,2, Wen-Hao Tang^1,2,3, Kai Hong^1,2, Li Zhang², Ying Lian², Hao-Cheng Lin^1,2, Hui Jiang^1,2,3 ¹ Department of Urology, Peking University Third Hospital, Beijing 100191, China ² Department of Reproductive Medicine Center, Peking University Third Hospital, Beijing 100191, China ³ Department of Human Sperm Bank, Peking University Third Hospital, Beijing 100191, China Correspondence Address: Hao-Cheng Lin, Department of Urology, Peking University Third Hospital, Beijing 100191, China; Department of Reproductive Medicine Center, Peking University Third Hospital, Beijing 100191, China Hui Jiang, Department of Urology, Peking University Third Hospital, Beijing 100191, China; Department of Reproductive Medicine Center, Peking University Third Hospital, Beijing 100191, China; Department of Human Sperm Bank, Peking University Third Hospital, Beijing 100191, China Source of Support: None, Conflict of Interest: None DOI: 10.4103/aja.aja_38_20 PMID: 32719193

We performed this study to evaluate the clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection (micro-TESE-ICSI) treatment that used fresh or cryopreserved sperm in patients with nonobstructive azoospermia (NOA). A total of 338 NOA patients with 344 consecutive cycles received treatment in the reproductive medicine center of Peking University Third Hospital in Beijing, China, from January 2014 to December 2017. Fresh oocytes and fresh sperm were used in 222 patients with 234 cycles (Group A). Fresh oocytes and cryopreserved sperm were used in 116 patients with 110 cycles (Group B). We compared patient characteristics, embryonic development, and pregnancy outcomes between Groups A and B. There was no statistical difference in the patient characteristics, and no differences were observed with fertilization or quality embryo rates between Groups A and B. The rates of clinical pregnancy and live birth were both higher for Group A than those for Group B (both P < 0.05). In conclusion, fresh testicular sperm appears to produce better ICSI outcomes than cryopreserved testicular sperm in patients with NOA.


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    -  Zhang HL
    -  Mao JM
    -  Liu DF
    -  Zhao LM
    -  Tang WH
    -  Hong K
    -  Zhang L
    -  Lian Y
    -  Lin HC
    -  Jiang H

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