Clinical significance of EPHX2 deregulation in prostate cancer Liu MS, Zhao H, Xu CX, Xie PB, Wang W, Yang YY, Lee WH, Jin Y, Zhou HQ, - Asian J Androl

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Clinical significance of EPHX2 deregulation in prostate cancer Ming-Sheng Liu¹, Hui Zhao², Chen-Xiang Xu¹, Ping-Bo Xie¹, Wei Wang¹, Ying-Yu Yang¹, Wen-Hui Lee^1,3, Yang Jin⁴, Hong-Qing Zhou¹ ¹ The Second Ward of Urology, Qujing Affiliated Hospital of Kunming Medical University, Qujing 655000, China ² Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming 650332, China ³ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China ⁴ Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo 0379, Norway Correspondence Address: Hong-Qing Zhou, The Second Ward of Urology, Qujing Affiliated Hospital of Kunming Medical University, Qujing 655000 China Yang Jin, Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo 0379, Norway Source of Support: None, Conflict of Interest: None DOI: 10.4103/aja.aja_34_20 PMID: 32687069

The arachidonic acid (AA) metabolic pathway participates in various physiological processes as well as in the development of malignancies. We analyzed genomic alterations in AA metabolic enzymes in the Cancer Genome Atlas (TCGA) prostate cancer (PCa) dataset and found that the gene encoding soluble epoxide hydrolase (EPHX2) is frequently deleted in PCa. EPHX2 mRNA and protein expression in PCa was examined in multiple datasets by differential gene expression analysis and in a tissue microarray by immunohistochemistry. The expression data were analyzed in conjunction with clinicopathological variables. Both the mRNA and protein expression levels of EPHX2 were significantly decreased in tumors compared with normal prostate tissues and were inversely correlated with the Gleason grade and disease-free survival time. Furthermore, EPHX2 mRNA expression was significantly decreased in metastatic and recurrent PCa compared with localized and primary PCa, respectively. In addition, EPHX2 protein expression correlated negatively with Ki67 expression. In conclusion, EPHX2 deregulation is significantly correlated with the clinical characteristics of PCa progression and may serve as a prognostic marker for PCa.


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    -  Liu MS
    -  Zhao H
    -  Xu CX
    -  Xie PB
    -  Wang W
    -  Yang YY
    -  Lee WH
    -  Jin Y
    -  Zhou HQ

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