REVIEW
Year : 2021  |  Volume : 23  |  Issue : 4  |  Page : 348-356

Testosterone, cardiomyopathies, and heart failure: a narrative review


1 Department of Cardiology, University of Medicine and Pharmacy, Craiova 200349, Romania
2 Department of Physiology, University of Medicine and Pharmacy, Craiova 200349, Romania

Correspondence Address:
Ionuţ Donoiu
Department of Cardiology, University of Medicine and Pharmacy, Craiova 200349
Romania
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aja.aja_80_20

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Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure.


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