ORIGINAL ARTICLE
Year : 2018  |  Volume : 20  |  Issue : 4  |  Page : 366-371

The performance of the new prognostic grade and stage groups in conservatively treated prostate cancer


1 Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
2 Department of Urology, Nanyang Second General Hospital, Nanyang 473012, China
3 Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
4 Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA

Correspondence Address:
Dr. Ren-Fang Xu
Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China

Dr. Xiao-Zhou He
Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aja.aja_5_18

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We evaluated the prognosis of the new grade groups and American Joint Committee on Cancer (AJCC) stage groups in men with prostate cancer (PCa) who were treated conservatively. A total of 13 798 eligible men were chosen from the Surveillance Epidemiology and End Results database. The new grade and AJCC stage groups were investigated on prostate biopsy specimens. Kaplan–Meier survival analysis and multivariable hazards models were applied to estimate the association of new grade and stage groups with overall survival (OS) and PCa-specific survival (CSS). Mean follow-up was 42.65 months (95% confidence interval: 42.47–42.84) in the entire cohort. The 3-year OS and CSS rates stepped down for grade groups 1–5 and AJCC stage groups I–IVB, respectively. After adjusting for clinical and pathological characteristics, all grade groups and AJCC stage groups were associated with higher all-cause and PCa-specific mortality compared to the reference group (all P ≤ 0.003). In conclusion, we evaluated the oncological outcome of the new grade and AJCC stage groups on biopsy specimens of conservatively treated PCa. These two novel clinically relevant classifications can assist physicians to determine different therapeutic strategies for PCa patients.


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