INVITED REVIEW
Year : 2018  |  Volume : 20  |  Issue : 3  |  Page : 244-252

Vitamin D in prostate cancer


Inova Schar Cancer Institute, Inova Health System, Fairfax, VA 22037, USA

Correspondence Address:
Donald L Trump
Inova Schar Cancer Institute, Inova Health System, Fairfax, VA 22037
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aja.aja_14_18

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Signaling through the vitamin D receptor has been shown to be biologically active and important in a number of preclinical studies in prostate and other cancers. Epidemiologic data also indicate that vitamin D signaling may be important in the cause and prognosis of prostate and other cancers. These data indicate that perturbation of vitamin D signaling may be a target for the prevention and treatment of prostate cancer. Large studies of vitamin D supplementation will be required to determine whether these observations can be translated into prevention strategies. This paper reviews the available data in the use of vitamin D compounds in the treatment of prostate cancer. Clinical data are limited which support the use of vitamin D compounds in the management of men with prostate cancer. However, clinical trials guided by existing preclinical data are limited.


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