INVITED REVIEW
Year : 2015  |  Volume : 17  |  Issue : 5  |  Page : 749-755

Understanding normal and abnormal development of the Wolffian/epididymal duct by using transgenic mice


1 Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Wakayama, Japan
2 Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA

Correspondence Address:
Barry T Hinton
Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.155540

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The development of the Wolffian/epididymal duct is crucial for proper function and, therefore, male fertility. The development of the epididymis is complex; the initial stages form as a transient embryonic kidney; then the mesonephros is formed, which in turn undergoes extensive morphogenesis under the influence of androgens and growth factors. Thus, understanding of its full development requires a wide and multidisciplinary view. This review focuses on mouse models that display abnormalities of the Wolffian duct and mesonephric development, the importance of these mouse models toward understanding male reproductive tract development, and how these models contribute to our understanding of clinical abnormalities in humans such as congenital anomalies of the kidney and urinary tract (CAKUT).


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