INVITED RESEARCH HIGHLIGHT
Year : 2015  |  Volume : 17  |  Issue : 4  |  Page : 646-652

Mechanisms of fertilization elucidated by gene-manipulated animals


Center for Genetic Analysis for Biological Responses, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565 0871, Japan

Correspondence Address:
Masaru Okabe
Center for Genetic Analysis for Biological Responses, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565 0871
Japan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.153299

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Capacitation and the acrosome reaction are key phenomena in mammalian fertilization. These phenomena were found more than 60 years ago. However, fundamental questions regarding the nature of capacitation and the timing of the acrosome reaction remain unsolved. Factors were postulated over time, but as their roles were not verified by gene-disruption experiments, widely accepted notions concerning the mechanism of fertilization are facing modifications. Today, although in vitro fertilization systems remain our central research tool, the importance of in vivo observations must be revisited. Here, primarily focusing on our own research, I summarize how in vivo observations using gene-manipulated animals have elucidated new concepts in the mechanisms of fertilization.


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