INVITED RESEARCH HIGHLIGHT
Year : 2015  |  Volume : 17  |  Issue : 4  |  Page : 623-627

Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models


1 Priority Research Centre in Reproductive Science, Discipline of Biological Sciences, Faculty of Science and IT, University of Newcastle, Callaghan, NSW, Australia; Animal Resource Centre for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
2 Priority Research Centre in Reproductive Science, Discipline of Biological Sciences, Faculty of Science and IT, University of Newcastle, Callaghan, NSW, Australia
3 Animal Resource Centre for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

Correspondence Address:
Masahito Ikawa
Animal Resource Centre for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.153851

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Gene disruption technology has long been beneficial for the study of male reproductive biology. However, because of the time and cost involved, this technology was not a viable method except in specialist laboratories. The advent of the CRISPR/Cas9 system of gene disruption has ushered in a new era of genetic investigation. Now, it is possible to generate gene-disrupted mouse models in very little time and at very little cost. This Highlight article discusses the application of this technology to study the genetics of male fertility and looks at some of the future uses of this system that could be used to reveal the essential and nonessential genetic components of male reproductive mechanisms.


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