ORIGINAL ARTICLE
Year : 2015  |  Volume : 17  |  Issue : 1  |  Page : 81-85

A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands


1 Department of Pharmacy, University of Naples, Federico II, Via D. Montesano 49; Interdepartmental Centre for Sexual Medicine, University of Naples, Federico II, Via S. Pansini 5, Naples, Italy
2 Department of Pharmacy, University of Naples, Federico II, Via D. Montesano 49, Naples, Italy
3 Interdepartmental Centre for Sexual Medicine; Department of Neurosciences, Human Reproduction and Odontostomatology, University of Naples Federico II, Via S. Pansini 5, Naples, Italy
4 Interdepartmental Centre for Sexual Medicine, University of Naples, Federico II, Via S. Pansini 5, Naples, Italy

Correspondence Address:
Emma Mitidieri
Department of Pharmacy, University of Naples, Federico II, Via D. Montesano 49, Naples
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.133322

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Urotensin-II (U-II) is a cyclic peptide that acts through a G protein-coupled receptor (urotensin-II receptor [UTR]) mainly involved in cardiovascular function in humans. The urotensinergic system is also implicated in the urogenital tract. Indeed, U-II relaxes human corpus cavernosum strips and causes an increase in intracavernous pressure (ICP) in rats. In light of this, the U-II/UTR pathway can be considered a new target for the treatment of erectile dysfunction. On this hypothesis, herein we report on two new UTR high affinity-agonists, P5U (H-Asp-c[Pen-Phe-Trp-Lys-Tyr-Cys]-Val-OH) and UPG84(H-Asp-c[Pen-Phe-DTrp-Orn-(pNH 2 ) Phe-Cys]-Val-OH). The effects of P5U and UPG84 were each compared separately with U-II by monitoring the ICP in anesthetized rats. Intracavernous injection of U-II (0.03-1 nmol), P5U (0.03-1 nmol) or UPG84 (0.03-1 nmol) caused an increase in ICP. P5U, in particular, elicited a significant increase in ICP as compared to U-II. The observed effect by using P5U at a dose of 0.1 nmol per rat was comparable to the effect elicited by U-II at a dose of 0.3 nmol. Moreover, UPG84 at the lowest dose (0.03 nmol) showed an effect similar to the highest dose of U-II (1 nmol). Furthermore, UPG84 was found to be more effective than P5U. Indeed, while the lowest dose of P5U (0.03 nmol) did not affect the ICP, UPG84, at the same dose, induced a prominent penile erection in rat. These compounds did not modify the blood pressure, which indicates a good safety profile. In conclusion, UPG84 and P5U may open new perspectives for the management of erectile dysfunction.


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