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INVITED COMMENTARY
Year : 2014  |  Volume : 16  |  Issue : 5  |  Page : 783

Re: New insights into SET protein during mouse spermatogenesis


The State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, China

Date of Web Publication13-Jun-2014

Correspondence Address:
Yu-Gui Cui
The State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.131708

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How to cite this article:
Cui YG. Re: New insights into SET protein during mouse spermatogenesis. Asian J Androl 2014;16:783

How to cite this URL:
Cui YG. Re: New insights into SET protein during mouse spermatogenesis. Asian J Androl [serial online] 2014 [cited 2021 Aug 2];16:783. Available from: https://www.ajandrology.com/text.asp?2014/16/5/783/131708 - DOI: 10.4103/1008-682X.131708

We are thankful to Dr. Yeste for the encouraging comments. [1] In the previous study, we revealed a specific, SET-initiated, PP2A-mediated, pathway that leads to the increased lyase activity of P450c17 in ovarian theca cells, by which SET regulates testosterone biosynthesis. How to work SET protein in Leydig cells is our new research interesting. Secondly, SET protein is a multifunctional protein involved in histone binding, transcription control, nucleosome assembly, and cell apoptosis. Very interestingly, we found the changing SET expression in the seminiferous epithelium at different stages in this manuscript. The highest level of SET protein was mainly in haploid and tetraploid cells of the prepubertal and adult mice, suggesting that SET is involved in the regulation of the complex, unique process of spermatogenesis. Our group is working on this role of SET protein as you proposed. It will contribute our understanding about molecular mechanism of spermatogenesis.

 
  References Top

1.Yeste M. New insights into SET protein during mouse spermatogenesis. Asian J Androl 2014; doi: 10.4103/1008-682X.131065.  Back to cited text no. 1
    




 

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