Table of Contents  
Year : 2014  |  Volume : 16  |  Issue : 4  |  Page : 639

Solving a bottleneck in animal models of peyronie's disease

1 Cranfield University, Bedfordshire, United Kingdom
2 Cranfield University, Bedfordshire; University College London Hospital, London, United Kingdom

Date of Web Publication08-Apr-2014

Correspondence Address:
David J Ralph
Cranfield University, Bedfordshire; University College London Hospital, London
United Kingdom
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1008-682X.126395

Rights and Permissions

How to cite this article:
Cellek S, Stebbeds W, Ralph DJ. Solving a bottleneck in animal models of peyronie's disease. Asian J Androl 2014;16:639

How to cite this URL:
Cellek S, Stebbeds W, Ralph DJ. Solving a bottleneck in animal models of peyronie's disease. Asian J Androl [serial online] 2014 [cited 2022 Jan 17];16:639. Available from: - DOI: 10.4103/1008-682X.126395

Peyronie's disease is characterized by the formation of a fibrous plaque in the tunica albuginea (TA) of the penis. It is a benign condition of unclear etiology, resulting in deformities such as curvature, indentation or shortening. The disease has been shown to be prevalent, especially in older men, and affects quality of life, principally through pain during erection, erectile dysfunction and associated psychological impact.

Medical treatment options are limited in number and efficacy for Peyronie's disease; leaving surgery as the only efficacious options for most patients. Development of novel therapeutic approaches is hampered by lack of reproducible, inexpensive and consistent animal models which mirror the clinical aspects of the disease, most importantly curvature formation and ossification. Previous models used injections of  transforming growth factor-beta [1] or fibrin [2] and surgical trauma to TA; [3] however, neither significant curvature nor ossification was achieved. Repeated administration of transforming growth factor-beta is required to achieve significant curvature. [4] Tsk genetic mouse has achieved curvature and cartilage formation, [5] but is an expensive model and the fibrosis is not limited to TA.

In the manuscript 'Tunica albuginea allograft: a new model of LaPeyronie's disease with penile curvature and subtunical ossification' published on Asian Journal of Andrology, Ferretti et al. [6] demonstrated that allograft TA transplantation in rats can achieve both significant curvature and some signs of ossification. Importantly the authors performed experiments in a temporal fashion, investigating various parameters at different time points (1, 3, 7 and 12 weeks) after allografting. By doing so, they were able to show that TA allografting was able to cause curvature and elastic fiber loss as early as 1 week after the operation, while erectile dysfunction was observed only at 12 th week. Curvature and elastic fiber loss was stable for 12 weeks. These results may suggest that the curvature can be simply due to disruption of normal morphology of the TA during tissue resection and grafting, not necessarily due to inflammatory processes triggered by the allograft. However, the authors' observation that '…when the grafted tunica was rejected from the corpus cavernosum, a new tunica appeared underneath the allograft. This new tunica, however, was rebuilt in an irregular fashion with disappearance of the two original layers organization (external longitudinal and internal circular). Cartilage-like areas were also seen in 30% of the cases with lacunae chambers and matrix material which fills space between lacunae' is extremely important as it suggests that ossification may be triggered in the newly formed TA in an inflammatory microenvironment. Obviously, further temporal analysis of this phenomenon (i.e., longer than 12 weeks) will be essential to understand how inflammation can lead to ossification in a disorganized TA tissue.

The perfect animal model of Peyronie's disease may not be here yet, but Ferretti et al. should be commended for their detailed temporal analysis and their very important observation which may lead to further basic science research as well as further development of this model.

  Competing Interests Top

The authors declare that they have no competing interests.

  References Top

1.El-Sakka AI, Hassoba HM, Chui RM, Bhatnagar RS, Dahiya R, et al. An animal model of Peyronie's-like condition associated with an increase of transforming growth factor beta mRNA and protein expression. J Urol 1997; 158: 2284−90.  Back to cited text no. 1
2.Davila HH, Ferrini MG, Rajfer J, Gonzalez-Cadavid NF. Fibrin as an inducer of fibrosis in the tunica albuginea of the rat: a new animal model of Peyronie's disease. BJU Int 2003; 91: 830−8.  Back to cited text no. 2
3.Bivalacqua TJ, Diner EK, Novak TE, Vohra Y, Sikka SC, et al. A rat model of Peyronie's disease associated with a decrease in erectile activity and an increase in inducible nitric oxide synthase protein expression. J Urol 2000; 163: 1992−8.  Back to cited text no. 3
4.Piao S, Ryu JK, Shin HY, Zhang L, Song SU, et al. Repeated intratunical injection of adenovirus expressing transforming growth factor-beta1 in a rat induces penile curvature with tunical fibrotic plaque: a useful model for the study of Peyronie's disease. Int J Androl 2008; 31: 346−53.  Back to cited text no. 4
5.Lucattelli M, Lunghi B, Fineschi S, Mirone V, d'Emmanuele di Villa Bianca R, et al. A new mouse model of Peyronie's disease: an increased expression of hypoxia-inducible factor-1 target genes during the development of penile changes. Int J Biochem Cell Biol 2008; 40: 2638−48.  Back to cited text no. 5
6.Ferretti L, Fandel TM, Qiu XF, Zhang HY, Orabi H, et al. Tunica albuginea allograft: a new model of LaPeyronie's disease with penile curvature and subtunical ossification. Asian J Androl 2014; doi: 10.4103/1008-682X.125900 [Epub ahead of print].  Back to cited text no. 6

This article has been cited by
1 Unwinding Fibrosis in Peyronieæs Disease
Marcus M. Ilg,Selim Cellek
The Journal of Sexual Medicine. 2020;
[Pubmed] | [DOI]
2 The mechanisms and potential of stem cell therapy for penile fibrosis
Uros Milenkovic,Maarten Albersen,Fabio Castiglione
Nature Reviews Urology. 2018;
[Pubmed] | [DOI]
3 Antifibrotic Synergy Between Phosphodiesterase Type 5 Inhibitors and Selective Oestrogen Receptor Modulators in Peyronieæs Disease Models
Marcus M. Ilg,Marta Mateus,William J. Stebbeds,Uros Milenkovic,Nim Christopher,Asif Muneer,Maarten Albersen,David J. Ralph,Selim Cellek
European Urology. 2018;
[Pubmed] | [DOI]


Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article
Competing Interests

 Article Access Statistics
    PDF Downloaded351    
    Comments [Add]    
    Cited by others 3    

Recommend this journal