Pathways linking ADT and various side effects

Androgen deprivation therapy (ADT), while potentially life prolonging when used in the correct setting, is known to have multiple side effects. This figure highlights the various biological mechanisms by which ADT can lead to increased risk of cardiovascular disease and osteoporosis. Moreover, this figure highlights some potential reasons to think that the risks may differ for GnRH (LHRH) agonists vs antagonists. Please refer to pages 3–10 for details.