Figure 4: KMT2D is positively correlated with the AR signaling pathway in PCa. (a) Heatmap of correlations (r) between normalized gene expression for the 27 robust target genes across all samples shown in Figure 2. (b) KMT2D mRNA levels were positively correlated with AR, CAMKK2, CDC20, and SPINK1 expression in PCa tissues in our cohort. (c) KMT2D mRNA levels were positively correlated with both gene and protein expression of AR in TCGA-PRAD. (d) mRNA expression of KMT2D in AR-V7-positive and AR-V7-negative cases from TCGA-PRAD. PCa: prostate cancer; TCGA-PRAD: The Cancer Genome Atlas Prostate Adenocarcinoma. All abbreviated names of genes are defined in [Supplementary Table 6].