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  Indian J Med Microbiol
 

Figure 2: The effect of 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic (8pCPT) on AE induced by protein kinase A inhibition. After 160 min of incubation (Control), various concentrations of 8pCPT were added and then 50 μmol l−1 N-[2-(p-bromocinnamylamino)ethyl]-5isoquinolinesulfonamide (H89) or 0.5 mmol l−1 1-methyl-3-isobutylxanthine (IBMX) were added. The values represent the mean ± standard deviation of duplicates from three experiments from three different donors.*P < 0.05,**P < 0.01, and***P < 0.001, significant difference compared to the corresponding control. AE: acrosomal exocytosis.

Figure 2: The effect of 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic (8pCPT) on AE induced by protein kinase A inhibition. After 160 min of incubation (Control), various concentrations of 8pCPT were added and then 50 μmol l<sup>−1</sup> N-[2-(p-bromocinnamylamino)ethyl]-5isoquinolinesulfonamide (H89) or 0.5 mmol l<sup>−1</sup> 1-methyl-3-isobutylxanthine (IBMX) were added. The values represent the mean ± standard deviation of duplicates from three experiments from three different donors.<sup>*</sup><i>P</i> < 0.05,<sup>**</sup><i>P</i> < 0.01, and<sup>***</sup><i>P</i> < 0.001, significant difference compared to the corresponding control. AE: acrosomal exocytosis.