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  Indian J Med Microbiol
 

Figure 1: Gene and protein structure of human BMI1. (a) BMI1 gene consists of 10 exons and 9 introns. (b) BMI1 protein starts from N-terminal RING domain required for interaction with RING1A/B, two NLS domains, HTH domain required for BMI1 localization at DNA damage site, to C-terminal PEST which is critical for BMI1 turnover. BMI1: B lymphoma Moloney murine leukemia virus insertion region 1; NLS: nuclear localization signal; HTH: helix-turn-helix; PEST: proline-glutamic acid-serine-threonine.

Figure 1: Gene and protein structure of human BMI1. (<b>a</b>) BMI1 gene consists of 10 exons and 9 introns. (<b>b</b>) BMI1 protein starts from N-terminal RING domain required for interaction with RING1A/B, two NLS domains, HTH domain required for BMI1 localization at DNA damage site, to C-terminal PEST which is critical for BMI1 turnover. BMI1: B lymphoma Moloney murine leukemia virus insertion region 1; NLS: nuclear localization signal; HTH: helix-turn-helix; PEST: proline-glutamic acid-serine-threonine.