Figure 3: Effects of GRK2 inhibition on erectile responses to electrical stimulation. Electrostimulation of the cavernous nerve was applied as voltage response (2.5 V, 5 V, and 7.5 V) at 15 Hz with a pulse width of 0.5 ms for 50 s. Erectile response is expressed as (a) ICP/MAP and (b) total ICP. Results were reported as mean ± standard deviation (s.d.). *P < 0.05, the indicated group versus control group; #P < 0.05, the indicated group versus T2DM+vehicle group; n = 20 per group. All results are representative of three independent experiments. GRK2: G protein-coupled receptor kinase 2; T2DM: type 2 diabetes mellitus; ICP: intracavernous pressure; MAP: mean arterial blood pressure.