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Figure 3: Cutoff value for the screening of Klinefelter syndrome. (a) RSD range for 46,XY samples. (b) Resolution of the highresolution melting assay for detecting 46,XY/47,XYY mosaicism. Statistical analysis: the line within the box denotes the median, the square within the box denotes the mean, the horizontal borders of each box denote the 25^{th} and 75^{th} percentiles, the whiskers denote the 5^{th} and 95^{th} percentiles, and the stars denote the maximum and minimum. (c) Analytical sensitivity and specificity for 46,XY/47,XYY mosaicism detection with different cutoff values. RSD: relative signal difference. 
