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  Indian J Med Microbiol
 

Figure 1: The role of PPARγ and ligands in prostate cancer growth: PPARγ agonists can inhibit the growth of prostate cancer cells, but this has been shown to be through PPARγ-independent mechanisms. New studies indicated that PPARγ played an oncogenic role in the development and progression of prostate cancer, both through AR-dependent and AR-independent means. Antagonists of PPARγ might be effective in the treatment of advanced prostate cancers and the prevention of prostate cancer development. PPARγ: peroxisome proliferator-activated receptor gamma; AR: androgen receptor; SP1: specificity protein 1; PC: prostate cancer.

Figure 1: The role of PPARγ and ligands in prostate cancer growth: PPARγ agonists can inhibit the growth of prostate cancer cells, but this has been shown to be through PPARγ-independent mechanisms. New studies indicated that PPARγ played an oncogenic role in the development and progression of prostate cancer, both through AR-dependent and AR-independent means. Antagonists of PPARγ might be effective in the treatment of advanced prostate cancers and the prevention of prostate cancer development. PPARγ: peroxisome proliferator-activated receptor gamma; AR: androgen receptor; SP1: specificity protein 1; PC: prostate cancer.