Figure 5: Knockdown of PGAM1 inhibits xenograft tumor growth in vivo. (a) The effects of PGAM1 knockdown by sh-PGAM1 transfected confirmed by Western blotting. (b) Gross observation of xenograft tumor size in NOD/SCID mice. Silencing of PGAM1 inhibited the tumor growth, including tumor (c) volume and (d) weight (n = 6). (e) H and E-stained paraffin-embedded sections obtained from xenografts. **P < 0.01. NC: negative controls; PGAM1: phosphoglycerate mutase 1; NOD: nonobese diabetic; SCID: severe combined immunodeficiency.