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  Indian J Med Microbiol
 

Figure 4: Tumor growth in nude mice following PlncRNA-1 knockdown in LNCaP cells. (a) Following PlncRNA-1 knockdown, LNCaP cells were significantly less tumorigenic compared with the mock group. (b and c) After subcutaneous implantation of LNCaP cells, a growth curve from 0 to 28 days was generated. The growth rate of LNCaP-derived tumors was significantly decreased after knockdown of PlncRNA-1. (d) Her-2 and cyclinD1 expression was detected by immunohistochemistry. Her-2 and cyclinD1 protein expression was downregulated after the knockdown of PlncRNA-1. (e) The expression levels of PlncRNA-1, Her-2, and cyclinD1 were detected using real-time PCR. Her-2 and cyclinD1 were downregulated after PlncRNA-1 knockdown. (f) The expression levels of Her-2 and cyclinD1 were detected by Western blotting. Her-2 and cyclinD1 were downregulated after the knockdown of PlncRNA-1

Figure 4: Tumor growth in nude mice following PlncRNA-1 knockdown in LNCaP cells. (a) Following PlncRNA-1 knockdown, LNCaP cells were significantly less tumorigenic compared with the mock group. (b and c) After subcutaneous implantation of LNCaP cells, a growth curve from 0 to 28 days was generated. The growth rate of LNCaP-derived tumors was significantly decreased after knockdown of PlncRNA-1. (d) Her-2 and cyclinD1 expression was detected by immunohistochemistry. Her-2 and cyclinD1 protein expression was downregulated after the knockdown of PlncRNA-1. (e) The expression levels of PlncRNA-1, Her-2, and cyclinD1 were detected using real-time PCR. Her-2 and cyclinD1 were downregulated after PlncRNA-1 knockdown. (f) The expression levels of Her-2 and cyclinD1 were detected by Western blotting. Her-2 and cyclinD1 were downregulated after the knockdown of PlncRNA-1