Figure 8: The interaction of BBR ( I ), INN ( II ) and EM1404 ( III ) with AKR1C3. BBR (yellow), INN (pink) and EM1404 (green). ( a ) The optimize graphic performance of ligands with AKR1C3. ( b ) The created surface around ligands in the active center of AKR1C3. ( c ) Ligand binding site atoms of AKR1C3. Hydrogen bonds and π-π interaction formed between BBR ( I ), INN ( II ) and EM1404 ( III ) with the active center of AKR1C3. Hydrogen bonds are shown by green dash lines. π-π interactions are shown by yellow solid line.