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  Indian J Med Microbiol
 

Figure 1: The synthesis of T/DHT under AKR1C3 catalysis. AKR1C3 catalyzes Δ4-adione to T and 5α-dione to DHT. SRD5A catalyzes Δ4-adione to 5α-dione and T to DHT. Then, T and DHT promote prostate cancer cell growth by activation of androgen receptor (AR).

Figure 1: The synthesis of T/DHT under AKR1C3 catalysis. AKR1C3 catalyzes Δ4-adione to T and 5α-dione to DHT. SRD5A catalyzes Δ4-adione to 5α-dione and T to DHT. Then, T and DHT promote prostate cancer cell growth by activation of androgen receptor (AR).