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  Indian J Med Microbiol
 

Figure 3: This diagram outlines a path to genomics-driven treatments in prostate cancer. Because of the prevalence of PI3K pathway activation, ETS rearrangements, and androgen signaling, genomic enrichment of patients for these common disease subsets may follow traditional trial structures including combination treatments. For rare or private molecular disease subsets, these patients may be better suited for studies based on the specific molecular aberration. For all treatments, repeat biopsy will be valuable for evaluating mechanisms of resistance and evolution of clonal and subclonal genomic alterations.6

Figure 3: This diagram outlines a path to genomics-driven treatments in prostate cancer. Because of the prevalence of PI3K pathway activation, ETS rearrangements, and androgen signaling, genomic enrichment of patients for these common disease subsets may follow traditional trial structures including combination treatments. For rare or private molecular disease subsets, these patients may be better suited for studies based on the specific molecular aberration. For all treatments, repeat biopsy will be valuable for evaluating mechanisms of resistance and evolution of clonal and subclonal genomic alterations.<sup>6</sup>