Figure 1: Kaplan–Meier analyses of BCR-free survival rates. (a) Comparison of upgraded and nonupgraded patients in Gleason score (3+3) cohort. The 5-year BCR-free survival rate was statistically significantly lower in the upgraded group (100.0% vs 96.7%, P = 0.047). (b) Comparison of downgraded and nondowngraded patients in Gleason score (4+4) cohort. The 5-year BCR-free survival rate was detected significantly higher in the downgraded group (71.1% vs 50.8%, P = 0.032).* P < 0.05 was considered statistically significant. BCR: biochemical recurrence.