Asian Journal of Andrology

INVITED REVIEW
Year
: 2016  |  Volume : 18  |  Issue : 2  |  Page : 186--193

Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation


Chak-Lam Cho1, Sandro C Esteves2, Ashok Agarwal3 
1 Division of Urology, Department of Surgery, Kwong Wah Hospital, 25 Waterloo Road, Yau Ma Tei, Hong Kong
2 ANDROFERT, Center for Male Reproduction, Av. Dr. Heitor Penteado 1464, Campinas, SP 13075-460, Brazil
3 American Center for Reproductive Medicine, 10681 Carnegie Avenue, X-11, Cleveland, OH 44195, USA

Correspondence Address:
Dr. Ashok Agarwal
American Center for Reproductive Medicine, 10681 Carnegie Avenue, X-11, Cleveland, OH 44195
USA

Varicocele has been associated with reduced male reproductive potential. With the advances in biomolecular techniques, it has been possible to better understand the mechanisms involved in testicular damage provoked by varicocele. Current evidence suggests the central role of reactive oxygen species (ROS) and the resultant oxidative stress (OS) in the pathogenesis of varicocele-associated male subfertility although the mechanisms have not yet been fully described and it is likely to be multifactorial. Excessive ROS is associated with sperm DNA fragmentation, which may mediate the clinical manifestation of poor sperm function and fertilization outcome related to varicocele. Testing of ROS/OS and DNA fragmentation has the potential to provide additional diagnostic and prognostic information compared to conventional semen analysis and may guide therapeutic management strategies in individual patient.


How to cite this article:
Cho CL, Esteves SC, Agarwal A. Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation.Asian J Androl 2016;18:186-193


How to cite this URL:
Cho CL, Esteves SC, Agarwal A. Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation. Asian J Androl [serial online] 2016 [cited 2020 Apr 10 ];18:186-193
Available from: http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=2;spage=186;epage=193;aulast=Cho;type=0