Asian Journal of Andrology

INVITED REVIEW
Year
: 2015  |  Volume : 17  |  Issue : 6  |  Page : 942--947

Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology


Li-Li Liu1, Hua Xian3, Jing-Chen Cao2, Chong Zhang2, Yong-Hui Zhang2, Miao-Miao Chen2, Yi Qian1, Ming Jiang3 
1 Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, Nantong University School of Medicine; Department of Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
2 Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, Nantong University School of Medicine, Nantong, Jiangsu, China
3 Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, Nantong University School of Medicine, Nantong, Jiangsu, China; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA

Correspondence Address:
Ming Jiang
Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, Nantong University School of Medicine, Nantong, Jiangsu, China; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPARγ acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic-pituitary-gonadal (HPG) axis, and is reciprocally regulated by HPG. In the human, PPARγ protein is highly expressed in ejaculated spermatozoa, implying a possible role of PPARγ signaling in regulating sperm energy dissipation. PPARγ protein is also expressed in Sertoli cells and germ cells (spermatocytes). Its activation can be induced during capacitation and the acrosome reaction. This mini-review will focus on how PPARγ signaling may affect fertility and sperm quality and the potential reversibility of these adverse effects.


How to cite this article:
Liu LL, Xian H, Cao JC, Zhang C, Zhang YH, Chen MM, Qian Y, Jiang M. Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology.Asian J Androl 2015;17:942-947


How to cite this URL:
Liu LL, Xian H, Cao JC, Zhang C, Zhang YH, Chen MM, Qian Y, Jiang M. Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology. Asian J Androl [serial online] 2015 [cited 2019 Dec 8 ];17:942-947
Available from: http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=6;spage=942;epage=947;aulast=Liu;type=0