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Role of tumor-associated immune cells in prostate cancer: angel or devil?


 Department of Urology, The Second Xiangya Hospital, Central South University, Changsha 410011, China

Correspondence Address:
Yin-Huai Wang,
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha 410011
China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aja.aja_47_19

PMID: 31134920

Prostate cancer is the most common malignancy in the reproductive system of older males. Androgen deprivation therapy (ADT) is an important treatment for prostate cancer patients. However, almost all prostate cancer patients unavoidably progress to the castration-resistant stage after ADT treatment. Recent studies have shown that tumor-associated immune cells play major roles in the initiation, progression, and metastasis of prostate cancer. Various phenotypes of tumor-associated immune cells have tumor-promoting or antitumor functions mediated by interacting with tumor cells. Here, we review the current knowledge of tumor-associated immune cells in prostate cancer.


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    -  Wu SQ
    -  Su H
    -  Wang YH
    -  Zhao XK
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