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B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancer


1 Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA
2 Xiangya School of Medicine, Central South University, Changsha 410008, China
3 Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China
4 Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China
5 Houston Methodist Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA
6 Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA

Correspondence Address:
Qi Cao,
Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA; Houston Methodist Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/aja.aja_38_18

PMID: 29862993

B lymphoma Moloney murine leukemia virus insertion region 1 (BMI1), a core member of polycomb repressive complex 1 (PRC1), has been intensely investigated in the field of cancer epigenetics for decades. Widely known as a critical regulator in cellular physiology, BMI1 is essential in self-renewal and differentiation in different lineages of stem cells. BMI1 also plays a significant role in cancer etiology for its involvement in pathological progress such as epithelial–mesenchymal transition (EMT) and cancer stem cell maintenance, propagation, and differentiation. Importantly, overexpression of BMI1 is predictive for drug resistance, tumor recurrence, and eventual therapy failure of various cancer subtypes, which renders the pharmacological targeting at BMI1 as a novel and promising therapeutic approach. The study on prostate cancer, a prevalent hormone-related cancer among men, has promoted enormous research advancements in cancer genetics and epigenetics. This review summarizes the role of BMI1 as an oncogenic and epigenetic regulator in tumor initiation, progression, and relapse of prostate cancer.


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