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Antiarrhythmic drug usage and prostate cancer: a population-based cohort study


1 Graduate Institute of Life Science, National Defense Medical Center, Taipei 110, Taiwan, China
2 Sleep Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan, China
3 School of Health Care Administration, Taipei Medical University, Taipei 110, Taiwan, China
4 Department of Urology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 110, Taiwan, China
5 Department of Urology, National Taiwan University Hospital, Hsin Chu Branch, Hsin Chu City 100, Taiwan, China
6 School of Public Health, Taipei Medical University, Taipei 100, Taiwan, China

Correspondence Address:
Chao-Yuan Huang,
Department of Urology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 110; Department of Urology, National Taiwan University Hospital, Hsin Chu Branch, Hsin Chu City 100; School of Public Health, Taipei Medical University, Taipei 100, Taiwan, China

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Source of Support: None, Conflict of Interest: None

Even though the relationship between antiarrhythmic drug usage and subsequent prostate cancer (PCa) risk has recently been highlighted, relevant findings in the previous literature are still inconsistent. In addition, very few studies have attempted to investigate the association between sodium channel blockers or potassium channel blockers for arrhythmia and the subsequent PCa risk. Therefore, this cohort study aimed to find the relationship between antiarrhythmic drug usage and the subsequent PCa risk using a population-based dataset. The data used in this study were derived from the Longitudinal Health Insurance Database 2005, Taiwan, China. We respectively identified 9988 sodium channel blocker users, 3663 potassium channel blocker users, 65 966 beta-blocker users, 23 366 calcium channel blockers users, and 7031 digoxin users as the study cohorts. The matched comparison cohorts (one comparison subject for each antiarrhythmic drug user) were selected from the same dataset. Each patient was tracked for a 5-year period to define those who were subsequently diagnosed with PCa. After adjusting for sociodemographic characteristics, comorbidities, and age, Cox proportional hazard regressions found that the hazard ratio (HR) of subsequent PCa for sodium channel blocker users was 1.12 (95% confidence interval [CI]: 0.84-1.50), for potassium channel blocker users was 0.89 (95% CI: 0.59-1.34), for beta-blocker users was 1.08 (95% CI: 0.96-1.22), for calcium channel blocker users was 1.14 (95% CI: 0.95-1.36), and for digoxin users was 0.89 (95% CI: 0.67-1.18), compared to their matched nonusers. We concluded that there were no statistical associations between different types of antiarrhythmic drug usage and subsequent PCa risk.


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