REVIEW
Year : 2019  |  Volume : 21  |  Issue : 3  |  Page : 296-299

Leptin and its actions on reproduction in males


1 Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sg Buloh 47000, Selangor, Malaysia
2 2I-PPerForM, Universiti Teknologi MARA, Sungai Buloh Campus, Sg Buloh 47000, Selangor, Malaysia

Correspondence Address:
Dr. Harbindar Jeet Singh
Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sg Buloh 47000, Selangor, Malaysia; 2I-PPerForM, Universiti Teknologi MARA, Sungai Buloh Campus, Sg Buloh 47000, Selangor, Malaysia

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aja.aja_98_18

Rights and Permissions

Leptin, an adipocyte-derived hormone, serves numerous physiological functions in the body, particularly during puberty and reproduction. The exact mechanism by which leptin activates the gonadotropin-releasing hormone (GnRH) neurons to trigger puberty and reproduction remains unclear. Given the widespread distribution of leptin receptors in the body, both central and peripheral mechanisms involving the hypothalamic-pituitary-gonadal axis have been hypothesized. Leptin is necessary for normal reproductive function, but when present in excess, it can have detrimental effects on the male reproductive system. Human and animal studies point to leptin as a link between infertility and obesity, a suggestion that is corroborated by findings of low sperm count, increased sperm abnormalities, oxidative stress, and increased leptin levels in obese men. In addition, daily leptin administration to normal-weight rats has been shown to result in similar abnormalities in sperm parameters. The major pathways causing these abnormalities remain unidentified; however, these adverse effects have been attributed to leptin-induced increased oxidative stress because they are prevented by concurrently administering melatonin. Studies on leptin and its impact on sperm function are highly relevant in understanding and managing male infertility, particularly in overweight and obese men.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1225    
    Printed117    
    Emailed0    
    PDF Downloaded157    
    Comments [Add]    
    Cited by others 1    

Recommend this journal