ORIGINAL ARTICLE
Year : 2019  |  Volume : 21  |  Issue : 2  |  Page : 115-120

The current status of hormone treatment for prostate cancer patients in Korean real-world practice: a multi-institutional observational study


1 Department of Urology, Seoul National University Bundang Hospital, Seongnam 13620, Korea
2 Department of Urology, Chonnam National University Hospital, Gwangju 61469, Korea
3 School of Medicine, Kyungpook National University Medical Center, Daegu 41404, Korea
4 Department of Urology, Konkuk University Medical Center, Seoul 05080, Korea
5 Department of Urology, Wonkwang University Hospital, Iksan 54538, Korea
6 Department of Urology, Daegu Catholic University Medical Center, Daegu 41911, Korea
7 Department of Urology, Ulsan University, Gangneung Asan Hospital, Gangneung 25440, Korea
8 Department of Urology, Chungbuk National University Hospital, Cheongju 28644, Korea
9 Department of Urology, Soonchunhyang University Hospital, Cheonan 31151, Korea
10 Department of Urology, Hallym University Sacred Heart Hospital, Anyang 14068, Korea
11 Department of Urology, Kangbuk Samsung Hospital, Seoul 03181, Korea
12 Department of Urology, Seoul St. Mary Hospital, Seoul 06591, Korea
13 ,

Correspondence Address:
Seok-Soo Byun
Department of Urology, Seoul National University Bundang Hospital, Seongnam 13620, Korea

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aja.aja_95_18

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We aimed to evaluate the current nationwide trend, efficacy, safety, and quality of life (QoL) profiles of hormone treatment in real-world practice settings for prostate cancer (PCa) patients in Korea. A total of 292 men with any biopsy-proven PCa (TanyNanyMany) from 12 institutions in Korea were included in this multi-institutional, observational study of prospectively collected data. All luteinizing hormone-releasing hormone (LHRH) agonists were allowed to be investigational drugs. Efficacy was defined as (1) the rate of castration (serum testosterone ≤50 ng dl−1) at 4-week visit and (2) breakthrough (serum testosterone >50 ng dl−1 after castration). Safety assessments included routine examinations for potential adverse events, laboratory tests, blood pressure, body weight, and bone mineral density (BMD, at baseline and at the last follow-up visit). QoL was assessed using the Expanded Prostate Cancer Index Composite-26 (EPIC-26). The most common initial therapeutic regimen was LHRH agonist with anti-androgen (78.0%), and the most commonly used LHRH agonist for combination and monotherapy was leuprolide (64.0% for combination and 58.0% for monotherapy). The castration and breakthrough rates were 78.4% and 6.6%, respectively. The laboratory results related to dyslipidemia worsened after 4 weeks of hormone treatment. In addition, the mean BMD T-score was significantly lower at the last follow-up (mean: −1.950) compared to baseline (mean: −0.195). The mean total EPIC-26 score decreased from 84.8 (standard deviation [s.d.]: 12.2) to 78.3 (s.d.: 8.1), with significant deterioration only in the urinary domain (mean: 23.5 at baseline and 21.9 at the 4-week visit). These findings demonstrate the nationwide trend of current practice settings in hormone treatment for PCa in Korea.


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