ORIGINAL ARTICLE
Year : 2019  |  Volume : 21  |  Issue : 1  |  Page : 80-85

Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression


1 Department of Surgery II, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
2 Department of Urology Surgery I, Cangzhou Central Hospital, Cangzhou 061000, China

Correspondence Address:
Bing-Hui Li
Department of Surgery II, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/aja.aja_70_18

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Lycopene is a natural compound that alleviates oxidative stress and inflammation, exerting therapeutic effects in a number of cancers. The aim of this study is to investigate the efficacy of lycopene in inhibiting prostate cancer. Cell viability assays indicated the dose- and time-dependent toxicity of lycopene in prostate cancer cells. Annexin V/propidium iodide double-staining assays revealed the strong apoptotic effects of lycopene. The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-α (TNF-α), in lycopene-treated cells were also reduced by lycopene treatment. With the increasing dose of lycopene, the survival of mice bearing prostate cancer xenografts was significantly improved (P < 0.01), and the tumor burden was significantly reduced (P < 0.01). Our results indicate that lycopene is a promising chemotherapy drug, which inhibits prostate cancer progression by suppressing the inflammatory response.


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