INVITED REVIEW
Year : 2016  |  Volume : 18  |  Issue : 2  |  Page : 194-201

Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele


1 Department of Surgery, Division of Urology, Human Reproduction Section, Sao Paulo Federal University, R. Embau, 231, 04039-060, Sao Paulo, Brazil
2 Department of Surgery, Division of Urology, Human Reproduction Section, Sao Paulo Federal University, R. Embau, 231, 04039-060; Sao Paulo Hospital, Sao Paulo, Brazil

Correspondence Address:
Dr. Ricardo Pimenta Bertolla
Department of Surgery, Division of Urology, Human Reproduction Section, Sao Paulo Federal University, R. Embau, 231, 04039-060; Sao Paulo Hospital, Sao Paulo
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.168788

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Varicocele, the most important treatable cause of male infertility, is present in 15% of adult males, 35% of men with primary infertility, and 80% of men with secondary infertility. On the other hand, 80% of these men will not present infertility. Therefore, there is a need to differentiate a varicocele that is exerting a deleterious effect that is treatable from a "silent" varicocele. Despite the growing evidence of the cellular effects of varicocele, its underlying molecular mechanisms are still eluding. Proteomics has become a promising area to determine the reproductive biology of semen as well as to improve diagnosis of male infertility. This review aims to discuss the state-of-art in seminal plasma proteomics in patients with varicocele to discuss the challenges in undertaking these studies, as well as the future outlook derived from the growing body of evidence on the seminal proteome.


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