INVITED REVIEW
Year : 2016  |  Volume : 18  |  Issue : 2  |  Page : 186-193

Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation


1 Division of Urology, Department of Surgery, Kwong Wah Hospital, 25 Waterloo Road, Yau Ma Tei, Hong Kong
2 ANDROFERT, Center for Male Reproduction, Av. Dr. Heitor Penteado 1464, Campinas, SP 13075-460, Brazil
3 American Center for Reproductive Medicine, 10681 Carnegie Avenue, X-11, Cleveland, OH 44195, USA

Correspondence Address:
Dr. Ashok Agarwal
American Center for Reproductive Medicine, 10681 Carnegie Avenue, X-11, Cleveland, OH 44195
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.170441

Rights and Permissions

Varicocele has been associated with reduced male reproductive potential. With the advances in biomolecular techniques, it has been possible to better understand the mechanisms involved in testicular damage provoked by varicocele. Current evidence suggests the central role of reactive oxygen species (ROS) and the resultant oxidative stress (OS) in the pathogenesis of varicocele-associated male subfertility although the mechanisms have not yet been fully described and it is likely to be multifactorial. Excessive ROS is associated with sperm DNA fragmentation, which may mediate the clinical manifestation of poor sperm function and fertilization outcome related to varicocele. Testing of ROS/OS and DNA fragmentation has the potential to provide additional diagnostic and prognostic information compared to conventional semen analysis and may guide therapeutic management strategies in individual patient.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2747    
    Printed88    
    Emailed0    
    PDF Downloaded594    
    Comments [Add]    
    Cited by others 46    

Recommend this journal