INVITED RESEARCH HIGHLIGHT
Year : 2015  |  Volume : 17  |  Issue : 6  |  Page : 878-881

Testosterone replacement therapy and the risk of prostate cancer


1 Division of Urology, University of Texas Medical School at Houston, Department of Urology, Houston, Texas, USA
2 Division of Urology, University of Texas Medical School at Houston, Department of Urology; University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA

Correspondence Address:
Run Wang
Division of Urology, University of Texas Medical School at Houston, Department of Urology; University of Texas MD Anderson Cancer Center, Houston, Texas 77030
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.150841

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Understanding the role of testosterone replacement therapy (TRT) in the development and progression of prostate cancer is an important concept in treating patients with symptoms of hypogonadism. This article revealed a small number of mostly retrospective, observational studies describing the use of TRT in the general population, in men with prostatic intraepithelial neoplasia (PIN), in men with a history of treated prostate cancer, and in men on active surveillance for prostate cancer. The current literature does not report a statistically significant increase in the development or progression of prostate cancer in men receiving testosterone replacement for symptomatic hypogonadism, and the prostate saturation theory provides a model explaining the basis for these results. The use of TRT in men with a history of prostate cancer is considered experimental, but future results from randomized controlled trials could lead to a change in our current treatment approach.


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