ORIGINAL ARTICLE
Year : 2015  |  Volume : 17  |  Issue : 6  |  Page : 1006-1011

Comparison of gene expression of the oncogenic Wnt/β-catenin signaling pathway components in the mouse and human epididymis


1 School of Agriculture, Ludong University; Central Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong, China
2 Central Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong, China
3 Central Laboratory, Yantai Yuhuangding Hospital; College of Life Science, Yantai University, Yantai, Shandong, China
4 College of Life Science, Yantai University, Yantai, Shandong, China

Correspondence Address:
Dr. Kai Wang
School of Agriculture, Ludong University; Central Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.157396

Rights and Permissions

β-catenin is an integral part of the Wnt signaling pathway and has been linked to tumorigenesis and multiple developmental processes. The high β-catenin expression with low tumor incidence in the human epididymis is thus intriguing. In the present study, the β-catenin gene and protein was found to be highly expressed in the murine caput epididymidis, and the protein mainly localized along the lateral plasma membranes of adjacent epithelial cells throughout both human and mouse epididymides. Furthermore, the adult mouse epididymis was found to express almost all the Wnt/β-catenin signaling pathway genes that were determined previously by our group in the human organ. Despite the differences in epididymal structure, the similar location of β-catenin and the high concordance of this pathway's components' gene expression in both the adult human and mouse epididymides make the mouse a suitable animal model for studying the anti-tumor mechanism of the epididymis. In addition, both the mRNA and protein expression of β-catenin shared a similar spatial expression as the mRNA of Ros1, a proto-oncogene and a key developmental regulator of the initial segment of the mouse epididymis. The observations on the parallel temporal expression of β-catenin and Ros1 during postnatal development raise the possibility that the canonical Wnt signaling pathway has an additional role in the postnatal development of mouse epididymis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1752    
    Printed34    
    Emailed0    
    PDF Downloaded239    
    Comments [Add]    
    Cited by others 3    

Recommend this journal