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AUTHOR REPLY
Year : 2014  |  Volume : 16  |  Issue : 6  |  Page : 921

Re: Is number of chiasmata an etiological factor of male infertility?


Unitat de Biologia Cel·lular, Facultat de Biociències, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès) 08193, Spain

Date of Web Publication29-Aug-2014

Correspondence Address:
Zaida Sarrate
Unitat de Biologia Cel·lular, Facultat de Biociències, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès) 08193
Spain
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.137681

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How to cite this article:
Sarrate Z, Vidal F, Blanco J. Re: Is number of chiasmata an etiological factor of male infertility?. Asian J Androl 2014;16:921

How to cite this URL:
Sarrate Z, Vidal F, Blanco J. Re: Is number of chiasmata an etiological factor of male infertility?. Asian J Androl [serial online] 2014 [cited 2019 Oct 24];16:921. Available from: http://www.ajandrology.com/text.asp?2014/16/6/921/137681 - DOI: 10.4103/1008-682X.137681

We would like to thank Kurpisz and Olszewska [1] for their commentary on our article [2] and we welcome the opportunity to discuss some of the issues addressed by our colleagues.

Meiotic studies are considered to have diagnostic value in cases of infertility of unknown aetiology. [3] We would like to remark that its application in the context of our article has been done in compliance with the existing legal framework. Concerning testicular biopsies from fertile individuals (the control population claimed by the authors) is a goal difficult to reach as it requires medical intervention without a diagnostic purpose.

As with any study, our study has limitations, and some are inherent to the biological samples affordable. However, the robustness of the results is supported by the statistical analysis based on Poisson regression models and designed to analyze, in an objective manner, chiasmata counts in relation to the preferential affectation of certain chromosomes, to the seminal parameters and to the karyotype. These statistical models correct limitations in the treatment of the data as under-dispersion and weighting. We are disappointed that the authors did not reflect our results in their interpretation of some specific figures. For instance, the mean values of chiasmata counts deduced from  [Table 2] are not weighted by the number of individuals. [2] Moreover, the authors grouped together results that have been obtained following differently analytical approaches (as indicated in [Table 2]). [2] Finally we would like to remark that 481 metaphases were informative in terms of chiasmata count, although in 14% of them some chromosomal units were not evaluable.

We are grateful for the interest shown in our manuscript. We are also intrigued by some of the issues opened by our research, and we are confident we will make progress on them in the next future.

 
  References Top

1.Kurpisz M, Olszewska M. Is number of chiasmata an etiological factor of male infertility? Asian J Androl 2014; doi: 10.4103/1008-682X.136442. [Epub ahead of print].  Back to cited text no. 1
    
2.Sarrate Z, Vidal F, Blanco J. Meiotic abnormalities in metaphase I human spermatocytes from infertile males: frequencies, chromosomes involved, and relationship with polymorphic karyotype and seminal parameters. Asian J Androl 2014; doi: 10.4103/1008-682X.135126. [Epub ahead of print].  Back to cited text no. 2
    
3.Egozcue J, Sarrate Z, Codina-Pascual M, Egozcue S, Oliver-Bonet M, et al. Meiotic abnormalities in infertile males. Cytogenet Genome Res 2005; 111: 337-42.  Back to cited text no. 3
    




 

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