|Year : 2014 | Volume
| Issue : 6 | Page : 921
Re: Is number of chiasmata an etiological factor of male infertility?
Zaida Sarrate, Francesca Vidal, Joan Blanco
Unitat de Biologia Cel·lular, Facultat de Biociències, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès) 08193, Spain
|Date of Web Publication||29-Aug-2014|
Unitat de Biologia Cel·lular, Facultat de Biociències, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès) 08193
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Sarrate Z, Vidal F, Blanco J. Re: Is number of chiasmata an etiological factor of male infertility?. Asian J Androl 2014;16:921
|How to cite this URL:|
Sarrate Z, Vidal F, Blanco J. Re: Is number of chiasmata an etiological factor of male infertility?. Asian J Androl [serial online] 2014 [cited 2019 Oct 24];16:921. Available from: http://www.ajandrology.com/text.asp?2014/16/6/921/137681 - DOI: 10.4103/1008-682X.137681
We would like to thank Kurpisz and Olszewska  for their commentary on our article  and we welcome the opportunity to discuss some of the issues addressed by our colleagues.
Meiotic studies are considered to have diagnostic value in cases of infertility of unknown aetiology.  We would like to remark that its application in the context of our article has been done in compliance with the existing legal framework. Concerning testicular biopsies from fertile individuals (the control population claimed by the authors) is a goal difficult to reach as it requires medical intervention without a diagnostic purpose.
As with any study, our study has limitations, and some are inherent to the biological samples affordable. However, the robustness of the results is supported by the statistical analysis based on Poisson regression models and designed to analyze, in an objective manner, chiasmata counts in relation to the preferential affectation of certain chromosomes, to the seminal parameters and to the karyotype. These statistical models correct limitations in the treatment of the data as under-dispersion and weighting. We are disappointed that the authors did not reflect our results in their interpretation of some specific figures. For instance, the mean values of chiasmata counts deduced from [Table 2] are not weighted by the number of individuals.  Moreover, the authors grouped together results that have been obtained following differently analytical approaches (as indicated in [Table 2]).  Finally we would like to remark that 481 metaphases were informative in terms of chiasmata count, although in 14% of them some chromosomal units were not evaluable.
We are grateful for the interest shown in our manuscript. We are also intrigued by some of the issues opened by our research, and we are confident we will make progress on them in the next future.
| References|| |
|1.||Kurpisz M, Olszewska M. Is number of chiasmata an etiological factor of male infertility? Asian J Androl 2014; doi: 10.4103/1008-682X.136442. [Epub ahead of print]. |
|2.||Sarrate Z, Vidal F, Blanco J. Meiotic abnormalities in metaphase I human spermatocytes from infertile males: frequencies, chromosomes involved, and relationship with polymorphic karyotype and seminal parameters. Asian J Androl 2014; doi: 10.4103/1008-682X.135126. [Epub ahead of print]. |
|3.||Egozcue J, Sarrate Z, Codina-Pascual M, Egozcue S, Oliver-Bonet M, et al. Meiotic abnormalities in infertile males. Cytogenet Genome Res 2005; 111: 337-42. |