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INVITED COMMENTARY
Year : 2014  |  Volume : 16  |  Issue : 4  |  Page : 643

Re: gene mapping of serotoninergic system polymorphisms provides insight on pathology and treatment of men with lifelong premature ejaculation


Department of Pharmaceutical Sciences, Division of Pharmacology, Utrecht University, Utrecht, The Netherlands

Date of Web Publication29-Apr-2014

Correspondence Address:
Marcel D Waldinger
Department of Pharmaceutical Sciences, Division of Pharmacology, Utrecht University, Utrecht
The Netherlands
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.126375

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How to cite this article:
Janssen PK, Schaik Rv, Olivier B, Waldinger MD. Re: gene mapping of serotoninergic system polymorphisms provides insight on pathology and treatment of men with lifelong premature ejaculation. Asian J Androl 2014;16:643

How to cite this URL:
Janssen PK, Schaik Rv, Olivier B, Waldinger MD. Re: gene mapping of serotoninergic system polymorphisms provides insight on pathology and treatment of men with lifelong premature ejaculation. Asian J Androl [serial online] 2014 [cited 2019 Oct 23];16:643. Available from: http://www.ajandrology.com/text.asp?2014/16/4/643/126375 - DOI: 10.4103/1008-682X.126375

We appreciate and thank Drs Saitz and Serefoglu for their positive and sympathetic words on our article. [1] Indeed, our genetic studies have shown that 5-HTTLPR polymorphism, 5-HT1A receptor gene polymorphism and 5-HT2C receptor gene polymorphism are associated with the duration of  the intravaginal ejaculatory latency time in men with lifelong premature ejaculation. In line with the remarks, [1] we hope that our stopwatch method will be used by other investigators to investigate the role of serotonergic gene polymorphisms on the duration of the intravaginal ejaculatory latency time. But lifelong premature ejaculation is not only characterized by persistent short intravaginal ejaculatory latency times, inability to delay ejaculation and negative personal consequences. Recently, lifelong premature ejaculation is characterized by an acute hypertonic state with facilitated ejaculation (ejaculatio praecox), together with either facilitated erections (erectio praecox) and/or facilitated penile detumescence (detumescentia praecox). [2] Future research is required to answer the question whether this combination of symptoms is associated with polymorphisms of various serotonergic gene and other neurotransmitter gene systems.

 
  References Top

1.Saitz TR, Serefoglu EC. Gene mapping of serotoninergic system polymorphisms provides insight on pathology and treatment of men with lifelong premature ejaculation. Asian J Androl 2014; doi: 10.4103/1008-682X.126372. In press.  Back to cited text no. 1
    
2.Waldinger MD. Ejaculatio praecox, erectio praecox, and detumescentia praecox as symptoms of a hypertonic state in lifelong premature ejaculation: a new hypothesis. Pharmacol Biochem Behav 2013 Dec 11. doi: 10.1016/j.pbb.2013.12.004. [Epub ahead of print].  Back to cited text no. 2
    




 

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