INVITED RESEARCH HIGHLIGHT
Year : 2014  |  Volume : 16  |  Issue : 3  |  Page : 418-419

Long noncoding RNA-mediated activation of androgen receptor in prostate cancer


Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Maryland, USA

Correspondence Address:
Gyorgy Petrovics
Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Maryland
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.126398

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Remarkable progress has been made in molecular characterization of prostate cancer (PCa) with continued innovations in high throughput technologies evaluating human cancer. [1],[2],[3] Since the completion of the Human Genome Project it has been estimated that only about 1.5%-2% of our genome codes for proteins. Various genome-wide approaches, e.g. the ENCODE project, revealed that a much larger percent of the genome is transcribed as non-protein coding (nc) RNA, including long noncoding (lnc) RNA (over 200 bps long). Although the biological roles of lncRNA (the 'dark matter of the genome') are not nearly as well-understood as the protein coding mRNAs, it is increasingly clear that they play important roles in almost every aspects of biology, including cancer biology. [4],[5] This is exemplified by recent genome-wide association studies revealing that over 80% of cancer-associated single nucleotide polymorphisms (SNPs) are in noncoding regions of the genome.


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