ORIGINAL ARTICLE
Year : 2014  |  Volume : 16  |  Issue : 2  |  Page : 305-308

Tissue elasticity displayed by elastography and its correlation with the characteristics of collagen type I and type III in prostatic stroma


1 Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China
2 Department of Pathology, Chinese People's Liberation Army General Hospital, Beijing, China

Correspondence Address:
Jie Tang
Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1008-682X.122582

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We investigated the prostate elasticity displayed by elastography and its correlation with the content and distribution of collagen type I (Col1) and type III (Col3). A total of 62 patients underwent transrectal real-time tissue elastography (TRTE) examinations. Targeted biopsies were performed after 12-core systematic biopsy. The tissues corresponding to the elastograms were stained with picric acid-sirius red. The distribution of Col1 and type Col3 was observed, and the collagen volume fraction (CVF) of these two types of collagen fibers was calculated. The CVFs of Col1 in the stiff and soft groups were 0.05 ± 0.02 and 0.02 ± 0.01 (P = 0.002), respectively. The CVFs of Col3 in the stiff and soft groups were 0.05 ± 0.04 and 0.07 ± 0.03 (P = 0.13), respectively. The circular analysis results showed that collagen fibers were disorganized both in the soft and stiff groups. Col1 and Col3 were mainly cross-linked, and some parallelization was observed in the sections. The distributions of Col1 and Col3 were different between the stiff and soft groups (P = 0.03). In conclusion, the texture of the prostate is due to the content of Col1 and its relative correlation with Col3.


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